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About  

U-48800 has formal name: 2-(2,4-dichlorophenyl)-N-((2S)-2-(dimethylamino)cyclohexyl)-N-methylacetamide. The chemical formula for U-48800 is C17H24Cl2N2O with a molecular weight of 343.291

U-48800 is synthetic opioid with distinct structural similarities to U-47700, a drug developed in the 1970s which had roughly 8 times the potency of morphine. This work led to the development of several compounds with kappa-opioid receptor selectivity, and one of the latest is U-48800.

Pharmacology:

Compared to U-47700, U-48800 adds a methylene spacer, which can be expected to increase this substance’s kappa opioid receptor potency substantially. It would be expected to produce euphoria, analgesia and sedation, but might also produce constipation and respiratory depression, 2 common side effects of similar compounds.  

Similar Compounds:

• Spiradoline
• U-77891
• U-69593
• U-47700
Due to a higher affinity to the κ‐receptor in comparison to the μ‐receptor, analgesia with fewer unwanted pharmacological effects. Expect Respiratory depression. Solimini et al recently reviewed the pharmacotoxicology of non‐fentanyl‐derived NSOs. This found u-48800 available as a research chemicals; of the opioid analgesic class to replace U‐47700 and that conventional drug tests do not detect such compounds. Due to the growing number of acute intoxication cases, they encouraged pharmacological, toxicological, and forensic research on these compounds to provide effective detection methods, amongst others.
Effect 
U-48800 produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria.
The toxicity and long-term health effects of recreational U-48800 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.

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